The Innovation Firm

Sai V. Seetharaman, Ph.D.

Practice Areas

Technologies

Education

  • Sri Sathya Sai Institute of Higher Learning (India), B.S. in Chemistry
  • Sri Sathya Sai Institute of Higher Learning (India), M.S. in Chemistry
  • University of Texas Health Science Center at San Antonio, Ph.D. in Biochemistry and Molecular Biology

Professional Associations

  • Boston Patent Law Association

Sai V. Seetharaman, Ph.D.

Sai V. Seetharaman, Ph.D. Attorney

Sai V. Seetharaman, Ph.D.

Patent Agent
Concord office
978.202.3493

Sai specializes in drafting and prosecuting patent applications and conducting patentability and freedom-to-operate searches in order to develop global prosecution strategies.  Sai practices in the fields of molecular biology, biophysics, organic synthesis, and biochemistry, with particular expertise in antibody engineering, site-specific conjugation, structure-based drug design and pharmaceutical formulations. 

Prior to joining the firm, Sai was a patent agent at ImmunoGen, Inc., a pharmaceutical company that develops therapies for the treatment of cancer.  He also interned at the Yale Office of Corporate Research, where he performed technical analysis, conducted prior art searches, interacted directly with inventors, prepared written reports with recommendations regarding patentability, and assisted in drafting patent claims. 

Before becoming a patent agent, Sai was a Howard Hughes Medical Institute (HHMI) Fellow at Yale University conducting research on multiple therapeutic areas including multiple drug resistance (MDR), cancer, neurodegenerative diseases, inflammation, diabetes and auto-immune disorders.  He determined multiple protein/RNA crystal structures, performed biophysical and structural characterization of bacterial ribosome in complex with different antibiotics, and developed a model system for studying the process of ribosome stalling and rescue which laid the framework for the development of several therapeutic agents to target multiple drug resistance (MDR) in bacteria.  Sai also has expertise in macromolecular x-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance (Biacore),  mass spectrometry of proteins and nucleic acids, isolation and purification of protein/nucleic acid complexes, and organic synthesis.

Publications

  • “Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome.”  Science.  2012 Mar 16; 335(6074):1370-2.
  • “Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.” Biochemistry.  2010 Jul 13; 49(27):5714-25.
  • “Structures of mouse SOD1 and human/mouse SOD1 chimeras.”  Arch Biochem Biophys. 2010 Nov 15; 503(2):183-90.
  • “Immature Copper-zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis.” Experimental Biology and Medicine.  2009 Oct; 234(10):1140-54.

Bar Admissions

  • U.S. Patent and Trademark Office
Biography

Sai specializes in drafting and prosecuting patent applications and conducting patentability and freedom-to-operate searches in order to develop global prosecution strategies.  Sai practices in the fields of molecular biology, biophysics, organic synthesis, and biochemistry, with particular expertise in antibody engineering, site-specific conjugation, structure-based drug design and pharmaceutical formulations. 

Prior to joining the firm, Sai was a patent agent at ImmunoGen, Inc., a pharmaceutical company that develops therapies for the treatment of cancer.  He also interned at the Yale Office of Corporate Research, where he performed technical analysis, conducted prior art searches, interacted directly with inventors, prepared written reports with recommendations regarding patentability, and assisted in drafting patent claims. 

Before becoming a patent agent, Sai was a Howard Hughes Medical Institute (HHMI) Fellow at Yale University conducting research on multiple therapeutic areas including multiple drug resistance (MDR), cancer, neurodegenerative diseases, inflammation, diabetes and auto-immune disorders.  He determined multiple protein/RNA crystal structures, performed biophysical and structural characterization of bacterial ribosome in complex with different antibiotics, and developed a model system for studying the process of ribosome stalling and rescue which laid the framework for the development of several therapeutic agents to target multiple drug resistance (MDR) in bacteria.  Sai also has expertise in macromolecular x-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance (Biacore),  mass spectrometry of proteins and nucleic acids, isolation and purification of protein/nucleic acid complexes, and organic synthesis.

Publications

  • “Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome.”  Science.  2012 Mar 16; 335(6074):1370-2.
  • “Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.” Biochemistry.  2010 Jul 13; 49(27):5714-25.
  • “Structures of mouse SOD1 and human/mouse SOD1 chimeras.”  Arch Biochem Biophys. 2010 Nov 15; 503(2):183-90.
  • “Immature Copper-zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis.” Experimental Biology and Medicine.  2009 Oct; 234(10):1140-54.
Education
  • Sri Sathya Sai Institute of Higher Learning (India), B.S. in Chemistry
  • Sri Sathya Sai Institute of Higher Learning (India), M.S. in Chemistry
  • University of Texas Health Science Center at San Antonio, Ph.D. in Biochemistry and Molecular Biology
Professional Associations
  • Boston Patent Law Association
Bar Admissions
  • U.S. Patent and Trademark Office

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